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Importance of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wu, Tung-Kung Wang, Tsai-Ting Chang, C. Liu, Yuan-Ting Shie, Wen-Shiang |
| Copyright Year | 2008 |
| Abstract | A contact mapping strategy was applied to identify putative amino acid residues that influence the oxidosqualene-lanosterol B-ring cyclization reaction. A bicyclic intermediate with two altered deprotonation products, in conjunction with lanosterol, were isolated from the ERG7(Y707X) mutants, indicating that the Tyr707 residue may play a functional role in stabilizing the chair-boat bicyclic C-8 cation and the lanosteryl C-8/C-9 cation intermediates. |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/ol802036c |
| Alternate Webpage(s) | http://life.nctu.edu.tw/~tkwu/paper/2008.Org.Lett.Importance%20of%20Saccharomyces%20cerevisiae%20Oxidosqualene-Lanosterol%20Cyclase%20Tyrosine%20707.pdf |
| Alternate Webpage(s) | https://ir.nctu.edu.tw/bitstream/11536/8159/1/000260534500063.pdf |
| PubMed reference number | 18842050 |
| Alternate Webpage(s) | https://doi.org/10.1021/ol802036c |
| Journal | Medline |
| Volume Number | 10 |
| Issue Number | 21 |
| Journal | Organic letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
