NDLI: The structure of the yeast plasma membrane SNARE complex reveals destabilizing water-filled cavities.

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The structure of the yeast plasma membrane SNARE complex reveals destabilizing water-filled cavities.

Content Provider	Semantic Scholar
Author	Strop, Pavel Kaiser, Stephen E. Vrljic, Marija Brunger, Axel T.
Copyright Year	2008
Abstract	SNARE proteins form a complex that leads to membrane fusion between vesicles, organelles, and plasma membrane in all eukaryotic cells. We report the 1.7A resolution structure of the SNARE complex that mediates exocytosis at the plasma membrane in the yeast Saccharomyces cerevisiae. Similar to its neuronal and endosomal homologues, the S. cerevisiae SNARE complex forms a parallel four-helix bundle in the center of which is an ionic layer. The S. cerevisiae SNARE complex exhibits increased helix bending near the ionic layer, contains water-filled cavities in the complex core, and exhibits reduced thermal stability relative to mammalian SNARE complexes. Mutagenesis experiments suggest that the water-filled cavities contribute to the lower stability of the S. cerevisiae complex.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://atbweb.stanford.edu/scripts/papers.php?sendfile=216
PubMed reference number	17956869v1
Volume Number	283
Issue Number	2
Journal	The Journal of biological chemistry
Language	English
Access Restriction	Open
Subject Keyword	Bending - Changing basic body position Eukaryotic Cells Exhibits as Topic Exocytosis Fill Mammals Membrane Fusion Organelles Plasma membrane SNARE complex Saccharomyces cerevisiae Vesicle (morphologic abnormality)
Content Type	Text
Resource Type	Article

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