NDLI: The cell polarity proteins Boi1p and Boi2p stimulate vesicle fusion at the plasma membrane of yeast cells.

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The cell polarity proteins Boi1p and Boi2p stimulate vesicle fusion at the plasma membrane of yeast cells.

Content Provider	Semantic Scholar
Author	Kustermann, Jochen Wu, Yehui Rieger, Lucia Dedden, Dirk Phan, Tamara Walther, Paul Duenkler, Alexander Johnsson, Nils
Copyright Year	2017
Abstract	Eukaryotic cells can direct secretion to defined regions of their plasma membrane. These regions are distinguished by an elaborate architecture of proteins and lipids that are specialized to capture and fuse post-Golgi vesicles. Here, we show that the proteins Boi1p and Boi2p are important elements of this area of active exocytosis at the tip of growing yeast cells. Cells lacking Boi1p and Boi2p accumulate secretory vesicles in their buds. The essential PH domains of Boi1p and Boi2p interact with Sec1p, a protein required for SNARE complex formation and vesicle fusion. Sec1p loses its tip localization in cells depleted of Boi1p and Boi2p but overexpression of Sec1p can partially compensate for their loss. The capacity to simultaneously bind phospholipids, Sec1p, multiple subunits of the exocyst, Cdc42p and the module for generating active Cdc42p identify Boi1p and Boi2p as essential mediators between exocytosis and polar growth.
Starting Page	2996
Ending Page	3008
Page Count	13
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.biorxiv.org/content/biorxiv/early/2017/05/31/144360.full.pdf
PubMed reference number	28751498v1
Alternate Webpage(s)	https://doi.org/10.1242/jcs.206334
DOI	10.1242/jcs.206334
Journal	Journal of cell science
Volume Number	130
Issue Number	18
Language	English
Access Restriction	Open
Subject Keyword	Cell secretion Exocytosis Plasma membrane SEC1P gene SNARE complex Secretory Vesicles Staphylococcal Protein A Vesicle (morphologic abnormality) exocyst polarity vesicle fusion
Content Type	Text
Resource Type	Article

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The cell polarity proteins Boi1p and Boi2p stimulate vesicle fusion at the plasma membrane of yeast cells

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