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HLA-B27 typing in the categorisation of uveitis in a HLA-B27 rich population.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Huhtinen, Minna Karma, Anni |
| Copyright Year | 2000 |
| Abstract | AIMS To determine whether HLA-B27 typing helps the clinician in the diagnostic examination of uveitis in a HLA-B27 rich population and also whether the clinical picture of HLA-B27 positive unilateral acute or recurrent anterior uveitis (AAU) is distinguishable from the idiopathic negative form. METHODS During a 3 year period 220 consecutive patients with undetermined uveitis at onset were examined in the Helsinki University Eye Clinic. HLA-B27 antigen was tested for 85% of the patients. Other laboratory or x ray examinations were performed on the basis of the anatomical classification of uveitis and the biomicroscopic features characteristic of uveitis associated systemic diseases. RESULTS HLA-B27 antigen was found significantly more often in patients with anterior (71%) and acute/recurrent unilateral (79%) uveitis than in patients with intermediate, posterior panuveitis (7%), and chronic (7%) or bilateral (12%) forms. Of the 16 cases of HLA-B27 negative unilateral AAU, five showed biomicroscopic features representing uveitis entities. The remaining 11 cases did not differ in any respect from the cases of HLA-B27 positive unilateral AAU. CONCLUSION HLA-B27 antigen helps the clinician in the diagnostic examination of unilateral AAU. Positive test results serve as a clue to search for spondyloarthropathies, and negative results indicate the need to look for specific uveitis entities and other systemic diseases. The occurrence of HLA-B27 positivity in conjunction with uveitis entities other than unilateral AAU is of the same level or less than in the population of Finland in general. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://bjo.bmj.com/content/bjophthalmol/84/4/413.full.pdf |
| PubMed reference number | 10729301v1 |
| Volume Number | 84 |
| Issue Number | 4 |
| Journal | The British journal of ophthalmology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anterior uveitis Endocrine System Diseases HLA Complex HLA-B27 Antigen Histocompatibility Antigens Class II Lupus Erythematosus, Systemic Panuveitis Patients Plain x-ray Spondylarthropathies |
| Content Type | Text |
| Resource Type | Article |
