Familial systemic lupus erythematosus: the role of genetic and environmental factors.

Content Provider	Semantic Scholar
Author	Eroglu, Gungor E. Kohler, Peter F.
Copyright Year	2002
Abstract	OBJECTIVE To examine the contribution of genetic and environmental factors to disease occurrence in 26 families with two or more members affected with systemic lupus erythematosus (SLE). METHODS Genetic and environmental factors were examined by HLA-A, B, C/DR typing and by determining the presence of lymphocytotoxic antibodies (LCA) in patients and their consanguineous and non-consanguineous relatives. RESULTS No association between SLE and HLA-A, B, C antigens was found. There was, however, a significant association with HLA-DR2 in white subjects with SLE. The most striking finding was that HLA sharing was increased among the affected members, suggesting genetic similarities. Seven of 14 sib pairs (50%) who had concordant SLE were HLA identical as opposed to an expected 25%. Another interesting finding was that 15/18 (83%) patients with SLE and 11/22 (50%) consanguineous relatives had LCA, while 1/9 (11%) spouses, and 2/42 (5%) healthy controls had these antibodies. CONCLUSION Genetic factors have a role in the development and expression of SLE. Environmental factors may trigger the disease in genetically susceptible hosts.
Starting Page	29
Ending Page	31
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ard.bmj.com/content/annrheumdis/61/1/29.full.pdf
PubMed reference number	11779754v1
Volume Number	61
Issue Number	1
Journal	Annals of the rheumatic diseases
Language	English
Access Restriction	Open
Subject Keyword	HLA-A Antigens HLA-DQ Antigens Histocompatibility Antigens Class II Lupus Erythematosus, Systemic Lupus Vulgaris Lymphocytotoxic Antibodies Patients
Content Type	Text
Resource Type	Article