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Measurement of HLA class I expression in ankylosing spondylitis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Creamer, Paul Edmonds, Joshua Sullivan, Jessica Matthews, Sita |
| Copyright Year | 1992 |
| Abstract | The importance of HLA-B27 in the pathogenesis of ankylosing spondylitis is uncertain: current evidence favours a role for the B27 molecule itself. The possibility that quantitative differences in HLA-B27 expression may exist between patients with ankylosing spondylitis, family members, and control subjects positive for B27 was examined using appropriate monoclonal antibodies, flow cytometry, and a 'model lymphocyte' coated with a known number of mouse immunoglobulin binding sites. No differences were found between the groups. HLA-A2, examined for comparison, was expressed in greater amounts than HLA-B27, but each contributed only 10-20% of the total class I antigens. Homozygotes expressed twice the amount of antigen expressed by heterozygotes. Synovial lymphocytes expressed more class I antigens than peripheral lymphocytes. |
| Starting Page | 89 |
| Ending Page | 90 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.st-va.ncbi.nlm.nih.gov/pmc/articles/PMC1012419/pdf/annrheumd00473-0038.pdf |
| PubMed reference number | 1444627v1 |
| Volume Number | 51 |
| Issue Number | 10 |
| Journal | Annals of the rheumatic diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Ankylosing spondylitis Binding Sites Flow Cytometry HIV Antigens HLA tissue typing antigens HLA-B27 Antigen HLA-B27 Bld Donr Ql HLA-DQ Antigens Heterozygote Histocompatibility Antigens Class II Homozygote Hyperostosis, Diffuse Idiopathic Skeletal Patients |
| Content Type | Text |
| Resource Type | Article |
