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LDL-lowering Independent Effects of Early Pre-treatment with High-dose Statins in Patients Undergoing Percutaneous Coronary Interventions
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nusca, Annunziata Melfi, Rosetta Patti, Giuseppe Sciascio, Germano Di |
| Copyright Year | 2011 |
| Abstract | Statins inhibit hepatic 3-hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) reductase with consequent suppression of cholesterol biosynthesis. The advent of these drugs has significantly impacted the treatment of cardiovascular disease with well documented benefit in primary and secondary prevention1-3. However, several clinical and basic science investigations suggested that the beneficial effects of statins may extend beyond their cholesterol lowering effects, the so-called “pleiotropic effects”; these include improving endothelial function, inhibiting vascular inflammation and oxidation4-7. CORRESPONDENCE |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.healthcare-bulletin.com/uploads/media/LDL-lowering_Independent_Effects_of.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 3-hydroxy-3-methylglutaryl-coenzyme A Cardiovascular Diseases Coenzyme A Hydroxymethylglutaryl-CoA reductase Impacted tooth Inhibition Simvastatin Zero suppression cholesterol biosynthesis |
| Content Type | Text |
| Resource Type | Article |
