NDLI: Outcomes from intracerebral hemorrhage among patients pre-treated with statins.

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Outcomes from intracerebral hemorrhage among patients pre-treated with statins.

Content Provider	Semantic Scholar
Author	Romero, Flávio Ramalho Bertolini, Eduardo De Freitas Veloso, Vanessa Nogueira Venturini, Leandro Figueiredo, Eberval Gadelha De
Copyright Year	2011
Abstract	OBJECTIVE 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, have been associated with improved clinical outcomes after ischemic stroke and subarachnoid hemorrhage, but with an increased risk of incidental spontaneous intracerebral hemorrhage (ICH). We investigated whether the statin use before ICH, was associated with functional independence, 90 days after treatment. METHOD We analyzed 124 consecutive ICH patients with 90-day outcome data who were enrolled in a prospective cohort study between 2006 and 2009. Eighty-three patients were included in this study. Among ICH survivors, univariate Cox regression models and Kaplan-Meier plots were used to determine subject characteristics that were associated with an increased risk of recurrence. Statin usage was determined through interviewing the patient at the time of ICH and confirmed by reviewing their medical records. Independent status was defined as Glasgow Outcome Scale grades 4 or 5. RESULTS Statins were used by 20 out of 83 patients (24%) before ICH onset. There was no effect from pre-ICH statin use on functional independence rates (28% versus 29%, P=0.84) or mortality (46% versus 45%, P=0.93). CONCLUSION Pre-ICH statin use is not associated with changes to ICH functional outcome or mortality.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.scielo.br/pdf/anp/v69n3/a08v69n3.pdf
PubMed reference number	21755120v1
Volume Number	69
Issue Number	3
Journal	Arquivos de neuro-psiquiatria
Language	English
Access Restriction	Open
Subject Keyword	3-hydroxy-3-methylglutaryl-coenzyme A Cerebral Infarction Coenzyme A Coenzymes Gastrointestinal Hemorrhage Grade Hydroxymethylglutaryl-CoA reductase Patients Review [Publication Type] Simvastatin Subarachnoid Hemorrhage Survivors variable, characteristic, factor
Content Type	Text
Resource Type	Article

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