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Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ye, Wen-Song Reis, André Fernandes Dubois-Laforgue, Danièle Bellanné-Chantelot, Christine Timsit, José Velho, Gilberto |
| Copyright Year | 2001 |
| Abstract | OBJECTIVE Allelic variations in the vitamin D receptor (VDR) gene were reported to modulate insulin secretion in response to glucose. VDR was investigated as a candidate gene for type 2 diabetes mellitus (T2DM). METHOD Four single nucleotide polymorphisms (SNPs) in intron 8 (BsmI, Tru9I, ApaI) and exon 9 (TaqI) of the VDR gene were examined in 309 unrelated French subjects with T2DM and 143 controls. RESULTS The distribution of alleles and genotypes of the four SNPs was similar in patients and controls. However, in patients whose age at diagnosis of diabetes was < or =45 years, homozygous subjects for the T-allele of the TaqI SNP had a higher body mass index (BMI) (31.7+/-6.7 kg/m2, P=0.0058) and an increased prevalence of obesity (81%, P=0.005) with respect to heterozygous subjects (27.9+/-5.0 kg/m2; 46%) or homozygous subjects for the t-allele (27.7+/-5.0 kg/m2; 52%). Similar results were observed for homozygous subjects for the b-allele of the BsmI SNP. Logistic regression analysis demonstrated that TT homozygosity was independently associated with obesity in these subjects (odds ratio, 4.64; 95% confidence interval (CI), 1.64-14.76; P=0.0056). CONCLUSION VDR is not a major gene for T2DM in French Caucasians. However, polymorphisms in the VDR gene are associated with the susceptibility to obesity in subjects with early-onset T2DM. The pathophysiological mechanisms of these associations remain unexplained, but they could be related to a direct effect of vitamin D in adypocyte differentiation and metabolism, or to an indirect effect by modulation of insulin secretion. |
| Starting Page | xlvi |
| Ending Page | xlviii |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.eje-online.org/content/145/2/181.full.pdf |
| Alternate Webpage(s) | https://eje.bioscientifica.com/downloadpdf/journals/eje/145/2/181.pdf |
| PubMed reference number | 11454514v1 |
| Volume Number | 145 |
| Issue Number | 2 |
| Journal | European journal of endocrinology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alleles Body mass index Confidence Intervals Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Genetic Polymorphism Genotype Glucose Homozygote Introns Kilogram Per Square Meter Mental association Nitroprusside Nucleotides Obesity Patients Single Nucleotide Polymorphism Vitamin D Vitamin D3 Receptor insulin secretion |
| Content Type | Text |
| Resource Type | Article |
