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Lack of association between glutathione s-transferase mu 1 (GSTM1) gene polymorphisms and obesity
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yang, Seung Ae |
| Copyright Year | 2017 |
| Abstract | Recent researches suggested that personal individual's genetic background is contributed to the susceptibility to obesity. The present of this study is to investigate whether single nucleotide polymorphisms (SNPs) of glutathione s-transferase mu 1 (GSTM1) gene are susceptibility to obesity in Korean population. In present study, two SNPs (rs1056806 [Asp142Asp], rs3815029 [promoter]) of GSTM1 gene were genotyped in 117 overweight/obese subjects with a body mass index (BMI)≥23 kg/m2 and 125 nonoverweight/obese with a BMI of 18.5-23.0 kg/m2. Genotyping of two SNPs (rs1056806 and rs3815029) was determined by sequencing after polymerase chain reaction. Logistic regression models (codominant, dominant, recessive, and log-additive models) and allele analysis were used to calculate odds ratio, 95% confidence interval, and P-values. Significant association was considered at P<0.05. Tested two SNPs in GSTM1 genes did not show any significant association with obesity (rs1056806, P=0.24 in codominant 1 model; rs3815029, P=0.59 in codominant 1, P=0.09 in codominant 2, P=0.16 in dominant, P=0.09 in recessive, and P=0.07 in log-additive models). In summary, these results indicate that SNPs of GSTM1 gene did not associated with susceptibility of obesity in the Korean population. |
| Starting Page | 608 |
| Ending Page | 612 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/ab/jer-13-5-608.PMC5667609.pdf |
| PubMed reference number | 5667609 |
| Alternate Webpage(s) | https://doi.org/10.12965/jer.1735128.564 |
| DOI | 10.12965/jer.1735128.564 |
| Journal | Journal of exercise rehabilitation |
| Volume Number | 13 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biopolymer Sequencing Body mass index Confidence Intervals Genetic Polymorphism Glutathione S-Transferase Mu Kilogram Per Square Meter Nucleotides Obesity Odds Ratio Overweight Polymerase Chain Reaction Single Nucleotide Polymorphism Transferase |
| Content Type | Text |
| Resource Type | Article |
