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Methylenetetrahydrofolate reductase tagging polymorphisms are associated with risk of non-small cell lung cancer in eastern Chinese Han population
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ding, Hao Wang, Yafeng Chen, Yuanmei Liu, Chao Qiu, Hao Kang, Mingqiang Tang, Weifeng |
| Copyright Year | 2017 |
| Abstract | Previous reports implicated 5,10-ethylenetetrahydrofolate reductase (MTHFR) polymorphisms acted as a potential risk factor for several cancers. In order to explore the effect of MTHFR SNPs on non-small cell lung cancer (NSCLC), we selected MTHFR tagging single nucleotide polymorphisms (SNPs) and carried out a case-control study to determine the potential relationship of MTHFR SNPs with NSCLC risk. Our study consisted of 521 NSCLC patients and 1,030 non-cancer controls. MTHFR SNPs were genotyped by SNPscanTM genotyping assay. Using four genetic models (additive, Homozygote, dominant, recessive), the genotype frequencies were compared using the chi-squared (χ2) test. Crude/adjusted odds ratios (ORs) with their 95% confidence intervals (CIs) were used to assess the difference for the genotype distribution. We found that MTHFR rs1801133 G>A polymorphism decreased the risk of overall NSCLC. In a subgroup analysis, MTHFR rs1801133 G>A polymorphism also decreased NSCLC risk in female, < 60 years and never smoking subgroups. However, we identified that MTHFR rs4845882 G>A polymorphism was associated with the development of NSCLC in female subgroup. In addition, MTHFR rs9651118 T>C polymorphism increased the risk of NSCLC in < 60 years, never smoking and BMI < 24 kg/m2 subgroups. In conclusion, the current study highlights MTHFR rs1801133 G>A variants decreases the risk of NSCLC. Nevertheless, MTHFR rs4845882 G>A and rs9651118 T > C polymorphisms may be associated with NSCLC susceptibility. Well-designed large-scale studies are needed to confirm these findings and explore the interactions of gene-gene and gene-environment involved in MTHFR SNPs and NSCLC. |
| Starting Page | 110326 |
| Ending Page | 110336 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 29299150v1 |
| Alternate Webpage(s) | https://doi.org/10.18632/oncotarget.22887 |
| DOI | 10.18632/oncotarget.22887 |
| Journal | Oncotarget |
| Volume Number | 8 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Confidence Intervals Genetic Polymorphism Genotype determination Homozygote Kilogram Per Square Meter Malignant Neoplasms Non-Small Cell Lung Carcinoma Odds Ratio Patients Single Nucleotide Polymorphism Small cell carcinoma of lung Subgroup A Nepoviruses |
| Content Type | Text |
| Resource Type | Article |
