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Optical Coherence Tomography Predictors for Edge Restenosis After Everolimus-Eluting Stent Implantation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ino, Yasushi Kubo, Takashi Matsuo, Yoshiki Yamaguchi, Tomoyuki Shiono, Yasutsugu Shimamura, Kunihiro Katayama, Yosuke Nakamura, Tomoko Aoki, Hiroshi Taruya, Akira Nishiguchi, Tsuyoshi Satogami, Keisuke Yamano, Takashi Kameyama, Takeyoshi Orii, Makoto Ota, Shingo Kuroi, Akio Kitabata, Hironori Tanaka, Atsushi Hozumi, Takeshi Akasaka, Takashi |
| Copyright Year | 2016 |
| Abstract | BACKGROUND Stent edge restenosis (SER) remains a potential limitation of drug-eluting stents. The aim of this study was to determine optical coherence tomography (OCT) predictors for angiographic late SER after everolimus-eluting stent implantation. METHODS AND RESULTS We retrospectively analyzed 319 patients who underwent OCT immediately after everolimus-eluting stent implantation and scheduled 9- to 12-month follow-up angiography. The binary angiographic SER rate was 10% (32/319) in the patients, 8.4% (32/382) in lesions, and 4.4% (33/744) in stent edge segments. In the stent edge segments at post stenting, OCT-derived lipidic plaque (61% versus 20%; P<0.001) was more often observed in the SER group, and OCT-measured minimum lumen area (4.13±2.61 versus 5.58±2.46 mm2; P=0.001) was significantly smaller in the SER group compared with the non-SER group. Multivariate analysis identified lipidic plaque (odds ratio: 5.99; 95% confidence interval: 2.89-12.81; P<0.001) and minimum lumen area (odds ratio: 0.64; 95% confidence interval: 0.42-0.96; P=0.029) as independent predictors of binary SER. Receiver-operating characteristic analysis demonstrated that lipid arc of 185° (sensitivity: 71%; specificity: 72%; area under the curve: 0.761) and minimum lumen area of 4.10 mm2 (sensitivity: 67%; specificity: 77%; area under the curve: 0.787) were optimal cutoff values for predicting ischemia-driven SER. CONCLUSIONS The present OCT study demonstrated that lipidic plaque and minimum lumen area in the stent edge segments at post stenting were associated with late SER after everolimus-eluting stent implantation. OCT provides valuable information to determine an appropriate landing zone for stent implantation. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 27688261 |
| Journal | Medline |
| Volume Number | 9 |
| Issue Number | 10 |
| Alternate Webpage(s) | http://circinterventions.ahajournals.org/content/circcvint/9/10/e004231.full.pdf?download=true |
| Alternate Webpage(s) | https://doi.org/10.1161/CIRCINTERVENTIONS.116.004231 |
| Journal | Circulation. Cardiovascular interventions |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
