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Intravascular ultrasound predictors for edge restenosis after newer generation drug-eluting stent implantation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kang, Soo-Jin Cho, Young-Rak Park, Gyung-Min Ahn, Jung-Min Kim, Won-Jang Lee, Jong-Young Park, Duk-Woo Lee, Seung-Whan Kim, Young-Hak Lee, Cheol Whan Mintz, Gary S. Park, Seong-Wook Park, Seung-Jin |
| Copyright Year | 2013 |
| Abstract | The aim of the present study was to assess the intravascular ultrasound predictors for angiographic edge restenosis after newer generation drug-eluting stent implantation. A total of 820 patients (987 lesions) who underwent newer generation drug-eluting stent placement (236 Endeavor zotarolimus-eluting stents, 246 Resolute zotarolimus-eluting stents, and 505 everolimus-eluting stents) with 9 months of angiographic surveillance were enrolled. The post-stenting angiographic and intravascular ultrasound images of 1,668 reference segments (681 proximal and 987 distal) were analyzed. Overall, 37% of angiographically normal proximal reference segments and 21% of angiographically normal distal reference segments had plaque burden >50%. In the overall cohort of 1,668 reference segments, 47 (2.8%) had 9-month angiographic edge restenosis (diameter stenosis >50%). Edge restenosis was predicted by a post-stenting reference segment plaque burden >54.5% (sensitivity 81%, specificity 80%) and a reference segment minimum lumen area of 5.7 mm(2) (sensitivity 72%, specificity 59%). The edge restenosis rate was 2.1% in the Endeavor zotarolimus-eluting stents, 2.4% in the Resolute zotarolimus-eluting stents, and 3.4% in the everolimus-eluting stents lesions (p = 0.311). The predictive cutoff of the reference plaque burden was 56.3% for Endeavor zotarolimus-eluting stents, 57.3% for Resolute zotarolimus-eluting stents, and 54.2% for everolimus-eluting stents. The criteria for residual plaque burden were similar between proximal and distal reference segments (56.4% vs 51.9%, respectively), but the minimum lumen area criteria were quite different (<7.1 mm(2) for proximal vs <4.8 mm(2) for distal reference segments). In conclusion, after newer drug-eluting stent implantation, edge restenosis was predicted by post-stenting reference segment plaque burden >55%. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.amjcard.2013.01.288 |
| Alternate Webpage(s) | http://cvrf.org/download/paper/2013_06.pdf |
| PubMed reference number | 23433757 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.amjcard.2013.01.288 |
| Journal | Medline |
| Volume Number | 111 |
| Issue Number | 10 |
| Journal | The American journal of cardiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
