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Treating children with inflammatory bowel disease: Current and new perspectives
| Content Provider | Semantic Scholar |
|---|---|
| Author | Guariso, Graziella Gasparetto, Marco Antonio |
| Copyright Year | 2017 |
| Abstract | Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gut characterised by alternating periods of remission and relapse. Whilst the mechanism underlying this disease is yet to be fully understood, old and newer generation treatments can only target selected pathways of this complex inflammatory process. This narrative review aims to provide an update on the most recent advances in treatment of paediatric IBD. A MEDLINE search was conducted using "paediatric inflammatory bowel disease", "paediatric Crohn's disease", "paediatric ulcerative colitis", "treatment", "therapy", "immunosuppressant", "biologic", "monitoring" and "biomarkers" as key words. Clinical trials, systematic reviews, and meta-analyses published between 2014 and 2016 were selected. Studies referring to earlier periods were also considered in case the data was relevant to our scope. Major advances have been achieved in monitoring the individual metabolism, toxicity and response to relevant medications in IBD including thiopurines and biologics. New biologics acting on novel mechanisms such as selective interference with lymphocyte trafficking are emerging treatment options. Current research is investing in the development of reliable prognostic biomarkers, aiming to move towards personalised treatments targeted to individual patients. |
| Starting Page | 5469 |
| Ending Page | 5485 |
| Page Count | 17 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 28852307v1 |
| Alternate Webpage(s) | https://doi.org/10.3748/wjg.v23.i30.5469 |
| DOI | 10.3748/wjg.v23.i30.5469 |
| Journal | World journal of gastroenterology |
| Volume Number | 23 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | ADENOSINE DEAMINASE Adverse reaction to drug Azathioprine Biological Factors Biological Markers Crohn Disease Disease Progression Ifosfamide Immunosuppressive Agents Inflammatory Bowel Diseases Intestinal Diseases Intestines Irritable Bowel Syndrome Meta Analysis (statistical procedure) Methotrexate Patients Pelvic Inflammatory Disease Review [Publication Type] Scientific Publication Thiopurine S-Methyltransferase Ulcer Ulcerative Colitis adalimumab aminosalicylate biology (field) infliximab mercaptopurine mesalamine thiopurine |
| Content Type | Text |
| Resource Type | Article |
