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Sensitive Liquid Chromatography / Tandem Mass Spectrometry Method for the Simultaneous Determination of Risperidone , Olanzapine , Quetiapine , Clozapine , Ziprasidone , Perospirone , Aripiprazole and Blonanserin in Human Serum
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tonooka, Keiko Yoshida, Lynn Tomobe, Koji Kunisue, Yoko Terada, Masaru Shinozuka, Tatsuo |
| Copyright Year | 2018 |
| Abstract | The sensitive method for the simultaneous determination of eight atypical antipsychotic drugs (risperidone, olanzapine, quetiapine, clozapine, ziprasidone, perospirone, aripiprazole and blonanserin) in human serum has been developed based on a high-performance liquid chromatography-tandem mass spectrometry (LC/MS/MS) with electrospray ionization (ESI). The chromatographic separation was performed on a Mightysil-RP-18 MS column (2.0 mm × 150 mm, particle size 3 μm). The mobile phase consisted of 10 mM formic ammonium buffer (pH 6.0) and acetonitrile and was delivered at a flow rate of 0.20 mL/min. The triple quadrupole mass spectrometer was operated in positive ion mode, and multiple reaction monitoring was used for drug quantification. Solid-phase extraction of the eight antipsychotic drugs added to the human serum was performed with an OasisHLB extraction cartridges column. The method was linear for the investigated drugs over the concentration range of 20 100 ng/mL. The recoveries of these drugs were in the range of 81.3% 140%. The intraday and inter day standard deviation (SD) values for all analytes were <0.10. Therefore, the selectivity, accuracy and precision of this method are sufficient for clinical and forensic studies. This simultaneous screening method will be also applicable to analyze other atypical antipsychotic drugs. How to cite this paper: Tonooka, K., Yoshida, L., Tomobe, K., Kunisue, Y., Terada, M. and Shinozuka, T. (2018) Sensitive Liquid Chromatography/Tandem Mass Spectrometry Method for the Simultaneous Determination of Risperidone, Olanzapine, Quetiapine, Clozapine, Ziprasidone, Perospirone, Aripiprazole and Blonanserin in Human Serum. American Journal of Analytical Chemistry, 9, 88-97. https://doi.org/10.4236/ajac.2018.92008 Received: December 27, 2017 Accepted: February 24, 2018 Published: February 27, 2018 Copyright © 2018 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution-NonCommercial International License (CC BY-NC 4.0). http://creativecommons.org/licenses/by-nc/4.0/ Open Access |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://file.scirp.org/pdf/AJAC_2018022614194178.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Ammonium ion:SCnc:Pt:Plas:Qn Antipsychotic Agents Buffers Cartridge device Clomiphene Clozapine Control theory Copyright Eluent Flatulence Ions Liquid Chromatography Mass Spectrometry Mass Spectrometers (device) Multistage interconnection networks Organic Chemistry Phenomena Particle Size Quadrupole Quantitation Recovery - action Risperidone Selectivity (electronic) Spectrometry, Mass, Electrospray Ionization Standard deviation Tandem Mass Spectrometry Unstable Medical Device Problem acetonitrile analyte aripiprazole blonanserin olanzapine perospirone quetiapine ziprasidone |
| Content Type | Text |
| Resource Type | Article |
