NDLI: R factors conferring resistance to trimethoprim but not sulphonamides.

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R factors conferring resistance to trimethoprim but not sulphonamides.

Content Provider	Semantic Scholar
Author	Hedges, Robert W. Datta, Naomi Fleming, Michael
Copyright Year	1972
Abstract	R factors conferring high-level resistance to trimethoprim and sulphonamides were identified in bacteria causing infections in patients at three London hospitals in 1971 (Fleming, Datta & Griineberg, 1972). All were members of the W compatability group and came from the Camden area (Datta & Hedges, 1972). In April 1972 strains of Escherichia coli highly resistant to trimethoprim were isolated from calves at Frant, Kent, which is about 30 miles from the Camden area of London. The calves had been treated with large doses of a trimethoprim-sulphonamide preparation (Fleming, in preparation). The trime t hoprim-resistant strains had various patterns of multiple drug resistance (always including resistance to sulphonamides) and from them various R factors were transferred to E. coli KI2. Trimethoprim resistance was transferred with resistance to streptomycin, separately from resistance to sulphonamides or other drugs. Methods were as described previously (Fleming et al. 1972). An example of the trimethoprim-streptomycin resistance factors (R483) was studied in strains of Escherichia coli K12. Methods were as described by Datta & Hedges (1972) and by Coetzee, Datta & Hedges (1972).
Starting Page	1433
Ending Page	1444
Page Count	12
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.microbiologyresearch.org/docserver/fulltext/micro/73/3/mic-73-3-573.pdf?accname=guest&checksum=C009EEB9D200E6777BD63ED9041FB182&expires=1539640594&id=id
Alternate Webpage(s)	http://www.microbiologyresearch.org/docserver/fulltext/micro/73/3/mic-73-3-573.pdf?accname=guest&checksum=B7FC65A4F85E2F183C8DCA7C86910954&expires=1542705497&id=id
PubMed reference number	4571517v1
Volume Number	73
Issue Number	3
Journal	Journal of general microbiology
Language	English
Access Restriction	Open
Subject Keyword	Infection Multi-Drug Resistance Patients R Factors Streptomycin Sulfonamides Trimethoprim Trimethoprim-Sulfamethoxazole Combination
Content Type	Text
Resource Type	Article

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