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Increased multi-drug resistant Escherichia coli from hospitals in Khartoum state, Sudan.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ibrahim, Mutasim E. Bilal, Naser Eldin Hamid, Mohamed E. |
| Copyright Year | 2012 |
| Abstract | BACKGROUND Multidrug-resistant Escherichia coli (MDR E. coli) has become a major public health concern in Sudan and many countries, causing failure in treatment with consequent huge health burden. OBJECTIVES To determine the prevalence and susceptibility of MDR E. coli isolated from patients in hospitals at Khartoum State. METHODS Between May to August 2011, E. coli (n = 232) isolated from clinical specimens, identified, tested their antimicrobials susceptibility and screened for extend spectrum รข-lactamase production as per standard methods. RESULTS Of the 232 E. coli isolates, the majority were from urine (65.1%). MDR E. coli were present in 214 (92.2%). Of these, the resistance rates were recorded to: amoxicillin 97.7%, cefuroxime 92.5%, trimethoprim-sulfamethoxazole 88.3%, tetracycline 77.1%, nalidixic acid 72%, ceftriaxone 64%, ciprofloxacin 58.4%, ofloxacin 55.1%, amoxicillin-clavulanate 50.4%, ceftazidime, gentamicin 35% each, nitrofurantoin 22.4%, chloramphenicol, tobramicin 18.2% each and amikacin 1.9%. Overall MDR E. coli, 53.3% were resistant to > 7 antimicrobial agents and ESBL was detected in 32.7%. Isolates from males were more resistant than those from females (p < 0.05). CONCLUSIONS Drug-resistance surveillance and epidemiological analysis of patient data is need periodically and can be informative for appropriate management of antimicrobial resistance. |
| Starting Page | 1318 |
| Ending Page | 1328 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.ajol.info/index.php/ahs/article/download/84460/74461 |
| Alternate Webpage(s) | https://tspace.library.utoronto.ca/bitstream/1807/51084/1/hs12059.pdf |
| PubMed reference number | 23382754v1 |
| Volume Number | 12 |
| Issue Number | 3 |
| Journal | African health sciences |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amikacin Amoxicillin / Clavulanate Ceftazidime Ceftriaxone Cefuroxime Chloramphenicol Ciprofloxacin Epidemiology Escherichia coli Gentamicins Infection Microbicides Multi-Drug Resistance Nalidixic Acid Nitrofurantoin Numerous Ofloxacin Patients Specimen Sulfamethoxazole Tetracycline Trimethoprim-Sulfamethoxazole Combination |
| Content Type | Text |
| Resource Type | Article |
