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Tuberculosis and trimethoprim-sulfamethoxazole.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Forgacs, Pierre Wengenack, Nancy L. Hall, Leslie J. Zimmerman, Sarah K. Silverman, Mark L. Roberts, Glenn D. |
| Copyright Year | 2009 |
| Abstract | The sulfonamides were the first drugs with antituberculous effects. Their use was abandoned and basically forgotten with the advent of streptomycin and isoniazid combination treatment. There is a widespread belief, apparently based on testing a single isolate on questionable media, that Mycobacterium tuberculosis is resistant to trimethoprim-sulfamethoxazole (TMP-SMX). We saw a complex immunocompromised patient with tuberculosis who was initially treated with TMP-SMX without antituberculous drugs and defervesced on this treatment. An isolate of M. tuberculosis from this patient was found to be sensitive to TMP-SMX. We examined how frequently M. tuberculosis is sensitive to TMP-SMX. Isolates were tested for susceptibility to TMP-SMX on supplemented Middlebrook 7H10 plates. We found that 43 of 44 (98%) isolates of M. tuberculosis were susceptible to the combination of < or = 1 microg/ml of TMP and 19 microg/ml of SMX (< or = 1/19 microg/ml). Thus, the vast majority of our M. tuberculosis isolates were susceptible to TMP-SMX at an MIC similar to that for Mycobacterium kansasii, Mycobacterium marinum, and sensitive rapidly growing mycobacteria, organisms successfully treated with TMP-SMX as part of the treatment regimen. It is possible that TMP-SMX may be useful in treating patients with multiple-drug-resistant and extended drug-resistant tuberculosis. We feel that a clinical trial looking at the effectiveness of TMP-SMX as an antituberculous drug is worthwhile. |
| Starting Page | 56 |
| Ending Page | 63 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://antimicrobe.org/h04c.files/history/AAC%20Tuberculosis%20and%20Trimethoprim%20Sulfamethoxazole.pdf |
| PubMed reference number | 19564358v1 |
| Alternate Webpage(s) | https://doi.org/10.1128/AAC.01658-08 |
| DOI | 10.1128/aac.01658-08 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume Number | 53 |
| Issue Number | 11 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Genus Mycobacterium Mycobacterium kansasii Mycobacterium marinum Patients Streptomycin Sulfamethoxazole Sulfonamides Trimethaphan Trimethoprim Trimethoprim-Sulfamethoxazole Combination Tuberculosis Tuberculosis, Pulmonary isoniazid |
| Content Type | Text |
| Resource Type | Article |
