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Endothelial progenitor cells contribute to the development of ovarian carcinoma tumor blood vessels
| Content Provider | Semantic Scholar |
|---|---|
| Author | Grigoraş, Dorin Pirtea, Laurenţiu Cornel Ceaușu, Raluca Amalia |
| Copyright Year | 2014 |
| Abstract | Only a few studies in the literature have reported the contribution of endothelial progenitor cells (EPCs) in ovarian tumors, and with regard to malignant tumors, the data on the pre-existing endothelium insertion rate and the extent to which these cells contribute to tumor angiogenesis is controversial. The present study demonstrated the existence of EPCs and evaluated the expression of two markers, AC133 (also known as cluster of differentiation 133 or prominin) and tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2), signaling the presence of EPCs in the pre-existing endothelium. In total, 62 female patients who were diagnosed with ovarian tumors were retrospectively selected over a four-year period. Immunohistochemical analyses used Tie2 and AC133 as primary antibodies. In total, 27.4% of ovarian tumor cases expressed AC133 and Tie2 in blood vessel endothelial cells. The expression of these two markers did not correlate with the clinicopathological prognostic parameters, histological type, vascular microdensity or vessel type. The expression of AC133 and Tie2 in blood vessel endothelial cells contributes to angiogenesis progression in cases where the budding process is reduced or absent, as shown by the inverse correlation with the rate of proliferation of the endothelial cells. |
| Starting Page | 1511 |
| Ending Page | 1514 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.spandidos-publications.com/ol/7/5/1511/download |
| PubMed reference number | 24765167v1 |
| Volume Number | 7 |
| Journal | Oncology letters |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | AC133 antigen Blood Vessel Tissue Endothelial Progenitor Cells Epithelial ovarian cancer Insertion Mutation Malignant Neoplasms PROM1 gene PROM1 wt Allele Protein Tyrosine Kinase TEK wt Allele Tumor Angiogenesis ovarian neoplasm pediatric intracranial germ cell brain tumor |
| Content Type | Text |
| Resource Type | Article |
