NDLI: Endothelial progenitor cells contribute to the development of ovarian carcinoma tumor blood vessels.

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Endothelial progenitor cells contribute to the development of ovarian carcinoma tumor blood vessels.

Content Provider	Europe PMC
Author	GRIGORAS, DORIN PIRTEA, LAURENŢIU CEAUSU, RALUCA AMALIA
Copyright Year	2014
Abstract	Only a few studies in the literature have reported the contribution of endothelial progenitor cells (EPCs) in ovarian tumors, and with regard to malignant tumors, the data on the pre-existing endothelium insertion rate and the extent to which these cells contribute to tumor angiogenesis is controversial. The present study demonstrated the existence of EPCs and evaluated the expression of two markers, AC133 (also known as cluster of differentiation 133 or prominin) and tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2), signaling the presence of EPCs in the pre-existing endothelium. In total, 62 female patients who were diagnosed with ovarian tumors were retrospectively selected over a four-year period. Immunohistochemical analyses used Tie2 and AC133 as primary antibodies. In total, 27.4% of ovarian tumor cases expressed AC133 and Tie2 in blood vessel endothelial cells. The expression of these two markers did not correlate with the clinicopathological prognostic parameters, histological type, vascular microdensity or vessel type. The expression of AC133 and Tie2 in blood vessel endothelial cells contributes to angiogenesis progression in cases where the budding process is reduced or absent, as shown by the inverse correlation with the rate of proliferation of the endothelial cells.
ISSN	17921074
Journal	Oncology Letters
Volume Number	7
PubMed Central reference number	PMC3997705
Issue Number	5
PubMed reference number	24765167
e-ISSN	17921082
DOI	10.3892/ol.2014.1917
Language	English
Publisher	D.A. Spandidos
Publisher Date	2014-02-26
Access Restriction	Open
Rights License	This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Copyright © 2014, Spandidos Publications
Subject Keyword	ovarian carcinoma endothelial progenitors cells angiogenesis
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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