Interaction of Duffy antigen receptor for chemokines and KAI1: a critical step in metastasis suppression.

Content Provider	Semantic Scholar
Author	Iiizumi, Megumi Bandyopadhyay, Sucharita Watabe, Kounosuke
Copyright Year	2007
Abstract	Tumor metastases suppressor protein KAI1/CD82 is capable of blocking the tumor metastases without affecting the primary tumor formation, and its expression is significantly down-regulated in many types of human cancers. However, the exact molecular mechanism of the suppressor function of KAI1 remains elusive. Evidence from our laboratory supports a model in which tumor cells dislodge from the primary tumor and intravasate into the blood or lymphatic vessels followed by attachment to the endothelial cell surface whereby KAI1 interacts with the Duffy antigen receptor for chemokines (DARC) protein. This interaction transmits a senescent signal to cancer cells expressing KAI1, whereas cells that lost KAI1 expression can proliferate, potentially giving rise to metastases. Our model of the mechanism of action of KAI1 shows that metastasis suppressor activity can be dependent on interaction with host tissue and explains how KAI1 suppresses metastasis without affecting primary tumor formation. Taken together, in vitro and in vivo studies identify the KAI1-DARC interaction as a potential target for cancer therapy.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/canres/67/4/1411.full.pdf
PubMed reference number	17308076v1
Volume Number	67
Issue Number	4
Journal	Cancer research
Language	English
Access Restriction	Open
Subject Keyword	ACKR1 gene Blood Vessel CD82 protein, human CD82 wt Allele Endothelial Cells Lymphatic vessel Malignant Neoplasms Metastasis Suppression Neoplasm Metastasis Receptors, Antigen Secondary Neoplasm cancer cell chemokine primary tumor
Content Type	Text
Resource Type	Article