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High Id1 expression is associated with poor prognosis in 237 patients with acute myeloid leukemia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tang, Ruoping Hirsch, P. Fava, Fanny Lapusan, Simona Marzac, Christophe Teyssandier, Irène Pardo, Júlia Relat Marie, Jean-Pierre Legrand, Ollivier |
| Copyright Year | 2009 |
| Abstract | Inhibitors of differentiation (Id) are a group of dominant inhibitors of basic helix-loop-helix transcriptional factors, which promote excessive proliferation, and also protect cells against drug-induced apoptosis in mammalians. Recently, Id1 has been identified as a common downstream target of several constitutively activated oncogenic tyrosine kinase, such as FLT3 internal tandem duplication, in leukemia cells. We analyzed Id1 expression as possible prognostic factor in 237 acute myeloid leukemia (AML) patients. High Id1 expression was associated with older age (P = .009) and with FLT3 internal tandem duplication (P = .003). However, 61% of the patients in the group of FLT3(-) AML were Id1(+), suggesting that other tyrosine kinases are involved. In whole population, high Id1 expression independently predicted shorter disease-free survival (P = .05) and overall survival (P = .003). In young patients (age |
| Starting Page | 2993 |
| Ending Page | 3000 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/114/14/2993.full.pdf?sso-checked=true |
| PubMed reference number | 19643984v1 |
| Alternate Webpage(s) | https://doi.org/10.1182/blood-2009-05-223115 |
| DOI | 10.1182/blood-2009-05-223115 |
| Journal | Blood |
| Volume Number | 114 |
| Issue Number | 14 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Apoptosis Biological Markers Classification Cytogenetics FLT3 Internal Tandem Duplication Forecast of outcome Gene Duplication Abnormality ID1 gene Leukemia, Myelocytic, Acute Myeloid Leukemia Overall Survival Patients Prognostic Factors Protein Tyrosine Kinase |
| Content Type | Text |
| Resource Type | Article |
