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KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shimada, Akira Taki, Tomohiko Tabuchi, Ken Tawa, Akio Horibe, Keizo Tsuchida, Masahiro Hanada, Ryoji Tsukimoto, Ichiro Hayashi, Yasuhide |
| Copyright Year | 2006 |
| Abstract | Patients with t(8;21) acute myeloid leukemia (AML) are considered to have a good prognosis; however, approximately 50% of them relapse. The genetic alterations associated with a poor outcome in t(8;21) AML remain unknown. Recently, aberrations of receptor tyrosine kinases (RTKs) were frequently found in patients with AML. However, the prevalence and prognostic impact of RTK aberrations in pediatric t(8;21) AML remains undetermined. Here, we found the kinase domain mutations of the KIT gene in 8 (17.4%) of 46 patients with t(8;21) AML among newly diagnosed pediatric patients with AML treated on the AML99 protocol in Japan. Significant differences between patients with or without KIT mutations were observed in the 4-year overall survival (50.0% versus 97.4%, P = .001), disease-free survival (37.5% versus 94.7%, P < .001) and relapse rate (47.0% versus 2.7%, P < .001). Furthermore, FLT3 internal tandem duplication was found in only 2 (4.3%) patients. These results suggested that KIT mutations are strongly associated with a poor prognosis in pediatric t(8;21) AML. |
| Starting Page | 793 |
| Ending Page | 800 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/107/5/1806.full.pdf?sso-checked=true |
| Alternate Webpage(s) | http://jplsg.jp/menu3_contents/menu_3_iinkai/AML16.pdf |
| PubMed reference number | 16291592v1 |
| Volume Number | 107 |
| Issue Number | 5 |
| Journal | Blood |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | FLT3 Internal Tandem Duplication FLT3 gene internal tandem duplication:PrThr:Pt:Bone mar:Ord:Molgen Forecast of outcome Gene Duplication Abnormality Leukemia, Myelocytic, Acute Mutation Myeloid Leukemia Overall Survival Patients Receptor Protein-Tyrosine Kinases Tyrosine pediatric acute myeloblastic leukemia recurrent childhood brain stem glioma t(8;21) |
| Content Type | Text |
| Resource Type | Article |
