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Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia
| Content Provider | Scilit |
|---|---|
| Author | Stirewalt, Derek L. Kopecky, Kenneth J. Meshinchi, Soheil Engel, Julia H. Pogosova-Agadjanyan, Era L. Linsley, Jeremy Slovak, Marilyn L. Willman, Cheryl L. Radich, Jerald P. |
| Copyright Year | 2006 |
| Description | FLT3 internal tandem duplications (FLT3/ITDs) in the juxtamembrane domain are found in approximately 25% of acute myeloid leukemia (AML) patients, ranging in size from 3 to hundreds of nucleotides. We examined whether the sizes of FLT3/ITDs were associated with clinical outcomes in 151 AML patients enrolled in Southwest Oncology Group studies: S9333 and S9500. FLT3/ITDs were identified in 32% of patients (median ITD size = 39 nucleotides; range, 15-153 nucleotides). The CR rates were 35%, 67%, and 52% for patients with large (≥ 40), small (< 40), and no ITDs, respectively (P = .19). Increasing ITD size was associated with decreasing OS (estimated 5-year OS: large = 13%, small = 26%, and no ITD = 21%, P = .072) and RFS (estimated 5-year RFS: large = 13%, small = 27%, and no ITD = 34%, P = .017). These studies suggest that ITD size may have prognostic significance. |
| Related Links | https://ashpublications.org/blood/article-pdf/107/9/3724/469826/zh800906003724.pdf |
| Ending Page | 3726 |
| Page Count | 3 |
| Starting Page | 3724 |
| DOI | 10.1182/blood-2005-08-3453 |
| Journal | Blood |
| Issue Number | 9 |
| Volume Number | 107 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2006-05-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Duplications Tandem Duplication Myeloid Leukemia Prognostic Significance Acute Myeloid Internal Tandem Flt3 Internal Journal: Blood (Vol- 109, Issue- 9) |
| Content Type | Text |
| Resource Type | Article |
