NDLI: Prevalence of multi-drug resistant Salmonella typhi among clinically diagnosed typhoid fever patients in Lagos, Nigeria.

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Prevalence of multi-drug resistant Salmonella typhi among clinically diagnosed typhoid fever patients in Lagos, Nigeria.

Content Provider	Semantic Scholar
Author	Akinyemi, Kabiru Olusegun Coker, Akitoye Olusegun Oyefolu, Akeeb Oriowo Bola Amorighoye, E. P. Omonigbehin, E. O.
Copyright Year	2000
Abstract	A total of 635 clinically diagnosed typhoid fever patients were bled from three different health institutions in the metropolis of Lagos, Nigeria over a period of 15 months, May 1997 to July 1998. Out of the total blood cultured, 101 (15.9%) isolates of Salmonella species were isolated of which 68 (67.3%) were S. typhi, 17 (16.8%) and 16 (15.8%) were S. paratyphi A. and S. arizonae respectively. The overall isolation rate of S. typhi among patients is 10.7%, with most isolates 45.9% found among the severely-ill young adults, age group 16-30 years. All isolates were subjected to anti-microbial susceptibility testing using 12 different antibiotics: chloramphenicol, ampicillin, cotrimoxazole, gentamicin, colistin sulfate, nalidixic acid, nitrofurantoin, cefotaxime, tetracycline, streptomycin, ofloxacin and ciprofloxacin. All the S. typhi and S. paratyphi A isolates showed resistance to two or more of the 10 of 12 antibiotics tested particularly the 3-first-line antibiotics commonly used (chloramphenicol, ampicillin and cotrimoxazole) in the treatment of typhoid fever in Nigeria. No isolate showed resistance to ofloxacin and ciprofloxacin, however, nalidixic acid and gentamicin showed a moderate and appreciable inhibition to most of our isolates.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.znaturforsch.com/ac/v55c/s55c0489.pdf
PubMed reference number	10928566v1
Volume Number	55
Issue Number	5-6
Journal	Zeitschrift fur Naturforschung. C, Journal of biosciences
Language	English
Access Restriction	Open
Subject Keyword	101 Mouse Ampicillin Cefotaxime Chloramphenicol Ciprofloxacin Colistin Sulfate Gentamicins Nalidixic Acid Nitrofurantoin Numerous Ofloxacin Patients Salmonella typhi Streptomycin Tetracycline Trimethoprim-Sulfamethoxazole Combination Typhoid Fever
Content Type	Text
Resource Type	Article

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