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Association between antimicrobial consumption and resistance in Escherichia coli.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bergman, Mary Lou Nyberg, Solja T. Huovinen, Pentti Paakkari, Pirkko Hakanen, Antti J. |
| Copyright Year | 2009 |
| Abstract | During a 9-year study period from 1997 through 2005, the association between antimicrobial resistance rates in Escherichia coli and outpatient antimicrobial consumption was investigated in 20 hospital districts in Finland. A total of 754,293 E. coli isolates, mainly from urine samples, were tested for antimicrobial resistance in 26 clinical microbiology laboratories. The following antimicrobials were studied: ampicillin, amoxicillin-clavulanate, cephalosporins, fluoroquinolones, trimethoprim, trimethoprim-sulfamethoxazole, pivmecillinam, and nitrofurantoin. We applied a protocol used in earlier studies in which the level of antimicrobial consumption over 1 year was compared with the level of resistance in the next year. Statistically significant associations were found for nitrofurantoin use versus nitrofurantoin resistance (P < 0.0001), cephalosporin use versus nitrofurantoin resistance (P = 0.0293), amoxicillin use versus fluoroquinolone resistance (P = 0.0031), and fluoroquinolone use versus ampicillin resistance (P = 0.0046). Interestingly, we found only a few associations between resistance and antimicrobial consumption. The majority of the associations studied were not significant, including the association between fluoroquinolone use and fluoroquinolone resistance. |
| Starting Page | 5 |
| Ending Page | 5 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://aac.asm.org/content/53/3/912.full.pdf |
| PubMed reference number | 19104012v1 |
| Alternate Webpage(s) | https://doi.org/10.1128/AAC.00856-08 |
| DOI | 10.1128/aac.00856-08 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume Number | 53 |
| Issue Number | 3 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amdinocillin Pivoxil Amoxicillin / Clavulanate Ampicillin Resistance Cephalosporins Fluoroquinolones Laboratory Mental association Microbicides Nitrofurantoin Sulfamethoxazole Trimethoprim Trimethoprim-Sulfamethoxazole Combination |
| Content Type | Text |
| Resource Type | Article |
