NDLI: Small adrenal glands in cats with feline interstitial cystitis.

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Small adrenal glands in cats with feline interstitial cystitis.

Content Provider	Semantic Scholar
Author	Westropp, J. L. Welk, Kristin A. Buffington, C. A. Tony
Copyright Year	2003
Abstract	PURPOSE We documented the uncoupling of sympathetic nervous system activity from the hypothalamic-pituitary-adrenal axis in cats with feline interstitial cystitis (FIC). Altered hypothalamic-pituitary-adrenal activity was recently suggested in some humans with interstitial cystitis (IC) but to our knowledge no information exists on adrenal gland size and histopathology in this disease. To investigate further adrenal function in cats with FIC we determined cortisol responses to 125 microg synthetic adrenocorticotropic hormone (ACTH) as well as adrenal size and histology. MATERIALS AND METHODS ACTH stimulation studies were performed in 11 healthy cats and 20 with FIC. Adrenal glands obtained at autopsy in 8 healthy cats and 13 with FIC were weighed, measured and examined histologically. RESULTS Cats with FIC had significantly decreased responses to ACTH (2-way repeated measures ANOVA p <0.05). Mean weight +/- SD (58 +/- 50 vs 241 +/- 60 mg) and volume (264 +/- 72 vs 410 +/- 115 mm3) of adrenal glands were significantly smaller in cats with FIC than in healthy cats (p <0.05). CONCLUSIONS These results suggest that cats with FIC may have mild primary adrenal insufficiency. Decreased adrenal size has been observed in patients with chronic fatigue syndrome, which can be a co-morbid condition in some patients with IC. If these abnormalities are confirmed in humans with IC, hormone replacement therapy may be indicated in select patients.
Starting Page	167202
Ending Page	167202
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://indoorpet.osu.edu/sites/indoorpet/files/assets/documents/hospital/indoorcat/westropp03.pdf
PubMed reference number	14634458v1
Volume Number	170
Issue Number	6
Part	1
Journal	The Journal of urology
Language	English
Access Restriction	Open
Subject Keyword	Addison Disease Adrenal Glands Adrenal gland hypofunction Axis vertebra CNS disorder Chronic Fatigue Syndrome Congenital Abnormality Corticotropin Cystitis Histopathology Hydrocortisone Patients Physiological Sexual Disorders Small Sympathetic Nervous System
Content Type	Text
Resource Type	Article

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