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Corticotropin-releasing hormone links pituitary adrenocorticotropin gene expression and release during adrenal insufficiency.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Muglia, Louis J. Jacobson, Lauren Luedke, Colten Vogt, Sherri K. Schaefer, Max Dikkes, Pieter Fukuda, Seiji Sakai, Yoshiyuki Suda, Toshio Majzoub, Joseph A. |
| Copyright Year | 2000 |
| Abstract | Corticotropin-releasing hormone (CRH)-deficient (KO) mice provide a unique system to define the role of CRH in regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Despite several manifestations of chronic glucocorticoid insufficiency, basal pituitary proopiomelanocortin (POMC) mRNA, adrenocorticotrophic hormone (ACTH) peptide content within the pituitary, and plasma ACTH concentrations are not elevated in CRH KO mice. The normal POMC mRNA content in KO mice is dependent upon residual glucocorticoid secretion, as it increases in both KO and WT mice after adrenalectomy; this increase is reversed by glucocorticoid, but not aldosterone, replacement. However, the normal plasma levels of ACTH in CRH KO mice are not dependent upon residual glucocorticoid secretion, because, after adrenalectomy, these levels do not undergo the normal increase seen in KO mice despite the increase in POMC mRNA content. Administration of CRH restores ACTH secretion to its expected high level in adrenalectomized CRH KO mice. Thus, in adrenal insufficiency, loss of glucocorticoid feedback by itself can increase POMC gene expression in the pituitary; but CRH action is essential for this to result in increased secretion of ACTH. This may explain why, after withdrawal of chronic glucocorticoid treatment, reactivation of CRH secretion is a necessary prerequisite for recovery from suppression of the HPA axis. |
| Starting Page | 2442 |
| Ending Page | 2445 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jci.org/articles/view/5250/version/1/pdf/render |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/5000/5250/JCI0005250.pdf |
| PubMed reference number | 10792002v1 |
| Volume Number | 105 |
| Issue Number | 9 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adrenal Glands Adrenal cortical hypofunction Adrenal gland hypofunction Adrenalectomy Aldosterone Axis vertebra Corticotropin-Releasing Hormone Epinephrine Gene Expression Pro-Opiomelanocortin corticotropin secretion glucocorticoid secretion |
| Content Type | Text |
| Resource Type | Article |
