NDLI: Synthesis and Pharmacological Evaluation of Some 3-( 4-( Substituted ) 2-morpholino-4-yl-4-phenyl-thiazole-5-carbonyl )-1-benzopyran-2one

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Synthesis and Pharmacological Evaluation of Some 3-( 4-( Substituted ) 2-morpholino-4-yl-4-phenyl-thiazole-5-carbonyl )-1-benzopyran-2one

Content Provider	Semantic Scholar
Author	Mansuri, Muzzamil M. Seth, Arun Molvi, Khurshid I. Prajapati, B. R. Desai, Devak G.
Copyright Year	2012
Abstract	M.M. Mansuri *, A.K. Seth, K.I. Molvi, B.R. Prajapati, D.G.Desai Prashant and Mittal Kansara Pharmacy College, Pipariya, Waghodia, Vadodara, Gujarat, India Department of Pharmacy, Sumandeep Vidyapeeth, Pipariya, Waghodia, Vadodara, Gujarat, India Ali-Allana College of Pharmacy, Department of Pharmaceutical Medicinal Chemistry, Akkalkuawa, Nandurbar, India. L.M.College of Pharmacy, Navrangpura, Ahmedabad, Gujarat-India. ABSTRACT Taking in to consideration of diverse biological activities of coumarin and thiazole derivatives, attempts have been made to attach a thiazole side chain at C-3 position of coumarin. In addition, to expand the structural diversity of synthetic courmarins for biological functions, the morpholine fusion at 2 position of thiazole was also attempted. The compounds MM3M1 was synthesized keeping coumarin-3-yl constant at fifth position, morpholine at 2 position and phenyl moiety at 4 position of thiazole nucleus. The compounds MM3M2, MM3M3 and MM3M4 were synthesized keeping coumarin-3yl constant at fifth position, morpholine at 2 position and introducing electron withdrawing group (-Cl) at ortho, meta and para position respectively in phenyl moiety at 4 position of thiazole nucleus. All the synthesized compounds were evaluated for their invitro antibacterial and anti-platelet activity. On the basis of structure-activity relationship studies of synthesized MM3M1MM3M4 it can be concluded that presence of 2-chlorophenyl group at the 4 position of the thiazole contributes significantly to antibacterial and anti-platelet activity profile of the candidates.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pharmasm.com/pdf_files/12_mansuri.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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