NDLI: Detection of antimicrobial resistance-associated proteins by titanium dioxide-facilitated intact bacteria mass spectrometry† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04089j

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Detection of antimicrobial resistance-associated proteins by titanium dioxide-facilitated intact bacteria mass spectrometry† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04089j

Content Provider	Semantic Scholar
Author	Zhu, Yingdi Gasilova, Natalia Jović, Milica Qiao, Liang Liu, Baohong Lovey, Lysiane Tissières Pick, Horst Girault, Hubert H.
Copyright Year	2018
Abstract	Titanium dioxide-modified target plates were developed to enhance intact bacteria analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The plates were designed to photocatalytically destroy the bacterial envelope structure and improve the ionization efficiency of intracellular components, thereby promoting the measurable mass range and the achievable detection sensitivity. Accordingly, a method for rapid detection of antimicrobial resistance-associated proteins, conferring bacterial resistance against antimicrobial drugs, was established by mass spectrometric fingerprinting of intact bacteria without the need for any sample pre-treatment. With this method, the variations in resistance proteins' expression levels within bacteria were quickly measured from the relative peak intensities. This approach of resistance protein detection directly from intact bacteria by mass spectrometry is useful for fast discrimination of antimicrobial-resistant bacteria from their non-resistant counterparts whilst performing species identification. Also, it could be used as a rapid and convenient way for initial determination of the underlying resistance mechanisms.
Starting Page	2212
Ending Page	2221
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1039/c7sc04089j
PubMed reference number	29719694
Journal	Medline
Volume Number	9
Alternate Webpage(s)	http://www.rsc.org/suppdata/c7/sc/c7sc04089j/c7sc04089j1.pdf
Alternate Webpage(s)	https://os.unil.cloud.switch.ch/tind-customer-epfl/24c8a471-9a37-4028-9bc0-d38da3c2c01c?AWSAccessKeyId=ded3589a13b4450889b2f728d54861a6&Expires=1581911419&Signature=yzAByCdAzg/1p2PVs0cIzCbGl/M%3D&response-content-disposition=attachment%3B+filename*%3DUTF-8''c7sc04089j.pdf%3Bpdfa&response-content-type=application/pdf
Alternate Webpage(s)	https://infoscience.epfl.ch/record/234500/files/c7sc04089j.pdf
Alternate Webpage(s)	https://pubs.rsc.org/en/content/articlepdf/2018/sc/c7sc04089j
Alternate Webpage(s)	https://doi.org/10.1039/c7sc04089j
Journal	Chemical science
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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Detection of antimicrobial resistance-associated proteins by titanium dioxide-facilitated intact bacteria mass spectrometry† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04089j

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