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Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9md00031c
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ballantine, Ross D. McCallion, Conor E. Nassour, Elie Tokajian, Sima Cochrane, Stephen A. |
| Copyright Year | 2019 |
| Abstract | Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as d/l diaminobutyric acid and d-allo-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain strong activity against multidrug-resistant Gram-negative bacteria. |
| Starting Page | 484 |
| Ending Page | 487 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C9MD00031C |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c9/md/c9md00031c/c9md00031c1.pdf |
| Alternate Webpage(s) | https://pure.qub.ac.uk/portal/files/166196670/c9md00031c.pdf |
| PubMed reference number | 31015912 |
| Alternate Webpage(s) | https://doi.org/10.1039/C9MD00031C |
| Journal | Medline |
| Volume Number | 10 |
| Journal | MedChemComm |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
