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Association between adrenal insufficiency and ventilator weaning.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Huang, Chung-Jen Lin, Horng-Chyuan |
| Copyright Year | 2006 |
| Abstract | RATIONALE Adrenal insufficiency is a common disorder in critically ill patients with mechanical ventilation and is usually associated with higher mortality and poor clinical outcome. OBJECTIVES To determine whether stress dose corticosteroid supplementation can improve ventilator weaning and clinical outcome in patients with adrenal insufficiency. METHODS A prospective, randomized, placebo controlled, double-blinded study was conducted in the intensive care unit of a tertiary teaching hospital. A total of 93 mechanically ventilated patients were enrolled in the ventilator weaning trial. Adrenal function was assessed in all patients. Patients with adrenal insufficiency were randomized to the treatment group (50 mg intravenous hydrocortisone every 6 h) and the placebo group. MEASUREMENTS AND MAIN RESULTS The successful ventilator weaning percentage was significantly higher in the adequate adrenal reserve group (88.4%) and in the stress dose hydrocortisone treatment group (91.4%) than in the placebo group (68.6%). The weaning period was shorter in the hydrocortisone treatment group than in the placebo group. No significant adverse effects were observed in the corticosteroid treatment group. CONCLUSIONS For patients with respiratory failure, early identification of adrenal insufficiency and appropriate supplementation with stress dose hydrocortisone increase the success of ventilator weaning and shortens the weaning period. |
| Starting Page | 1 |
| Ending Page | 2 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ccmpitt.com/ebm/adrenal%20insufficiency/Association%20between%20adrenal%20insufficiency%20and%20ventilator%20weaning.pdf |
| PubMed reference number | 16272449v1 |
| Volume Number | 173 |
| Issue Number | 3 |
| Journal | American journal of respiratory and critical care medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adrenal Cortex Hormones Adrenal Glands Adrenal cortical hypofunction Adrenal gland hypofunction Adverse effects Aortic Valve Insufficiency Critical Illness Double-Blind Method Epinephrine Hydrocortisone Manuscripts Patients Pneumonia, Ventilator-Associated Respiration Respiratory Insufficiency Teaching Hospitals Tracheal Extubation Ventilator - respiratory equipment Wean from ventilator (procedure) intensive care unit tertiary |
| Content Type | Text |
| Resource Type | Article |
