Loading...
Please wait, while we are loading the content...
Diagnosis of adrenal failure in critically ill patients.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Moraes, Rafael Barberena Czepielewski, Mauro Antônio Friedman, Gilberto Borba, Evandro Lucas De |
| Copyright Year | 2011 |
| Abstract | In the last two decades there was important evolution on the knowledge of the function of the hypothalamic-pituitary-adrenal axis. In the last decade, the expression "relative adrenal insufficiency" (RAI) was created, and more recently "critical illness-related corticosteroid insufficiency" (CIRCI) was used to designate those patients in which cortisol production was not sufficiently increased in stress situations. Patients with CIRCI have elevated hospital morbidity and mortality. Currently, there is a wide discussion about diagnostic criteria for this dysfunction. Besides basal cortisol, some publications now study the role of other tests, such as cortrosyn test - either in low (1 μg) or high doses (250 μg); free cortisol, salivary cortisol, metyrapone test and others. With this review, we aimed at summarizing the results of the most influent papers that intended to define diagnostic criteria for CIRCI. We also suggest an approach for CIRCI diagnosis and make it clear that the decision about steroid therapy in septic shock patients is matter apart from RAI. |
| Starting Page | 295 |
| Ending Page | 302 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.aem-sbem.com/media/uploads/01_ABEM_555.pdf |
| Alternate Webpage(s) | http://www.lume.ufrgs.br/bitstream/handle/10183/40230/000785930.pdf?sequence=1 |
| PubMed reference number | 21881811v1 |
| Volume Number | 55 |
| Issue Number | 5 |
| Journal | Arquivos brasileiros de endocrinologia e metabologia |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adrenal Cortex Hormones Adrenal Glands Adrenal gland hypofunction Axis vertebra Critical Illness Epinephrine Hydrocortisone Illness (finding) Metyrapone Morbidity - disease rate Paper Patients Pulmonary Valve Insufficiency Septic Shock Steroids diagnostic criteria |
| Content Type | Text |
| Resource Type | Article |
