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Slow presynaptic and fast postsynaptic components of compound long-term potentiation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bayazitov, Ildar T. Richardson, Robert J. Fricke, Robert G. Zakharenko, Stanislav S. |
| Copyright Year | 2007 |
| Abstract | Long-term potentiation (LTP) mediates learning and memory in the mammalian hippocampus. Whether a presynaptic or postsynaptic neuron principally enhances synaptic transmission during LTP remains controversial. Acute hippocampal slices were made from transgenic mouse strains that express synaptopHluorin in neurons. SynaptopHluorin is an indicator of synaptic vesicle recycling; thus, we monitored functional changes in presynaptic boutons of CA3 pyramidal cells by measuring changes in synaptopHluorin fluorescence. Simultaneously, we recorded field excitatory postsynaptic potentials to monitor changes in the strength of excitatory synapses between CA3 and CA1 pyramidal neurons. We found that LTP consists of two components, a slow presynaptic component and a fast postsynaptic component. The presynaptic mechanisms contribute mostly to the late phase of compound LTP, whereas the postsynaptic mechanisms are crucial during the early phase of LTP. We also found that protein kinase A (PKA) and L-type voltage-gated calcium channels are crucial for the expression of the presynaptic component of compound LTP, and NMDA channels are essential for that of the postsynaptic component of LTP. These data are the first direct evidence that presynaptic and postsynaptic components of LTP are temporally and mechanistically distinct. |
| Starting Page | 1973 |
| Ending Page | 1978 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jneurosci.org/content/jneuro/27/43/11510.full.pdf |
| PubMed reference number | 17959794v1 |
| Volume Number | 27 |
| Issue Number | 43 |
| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | CA1 field CA3 field Calcium Cyclic AMP-Dependent Protein Kinases Excitatory Amino Acids Fluorescence Long-Term Potentiation Mammals Mice, Transgenic N-Methylaspartate Neurons Postsynaptic Potentials Pyramidal Cells Synapses Synaptic Transmission Synaptic Vesicles Vesicle (morphologic abnormality) chemosensitization/potentiation synaptic vesicle recycling |
| Content Type | Text |
| Resource Type | Article |
