NDLI: Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation.

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Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation.

Content Provider	Semantic Scholar
Author	Deane, Emily C. Ilie, Alina Elena Sizdahkhani, Saman Gupta, Micaela Das Orlowski, John McKinney, Rebecca Anne
Copyright Year	2013
Abstract	Postsynaptic endosomal trafficking has emerged as a principal regulatory mechanism of structural and functional plasticity of glutamatergic synapses. Recycling endosomes perform activity-dependent transport of AMPA receptors (AMPARs) and lipids to the postsynaptic membrane, activities that are known to contribute to long-term synaptic potentiation and hypothesized to subserve learning and memory processes in the brain. Recently, genetic defects in a widely expressed vesicular pH-regulating transporter, the Na(+)/H(+) exchanger NHE6 isoform, have been implicated in neurodevelopmental disorders including severe X-linked mental retardation and autism. However, little information is available regarding the cellular properties of this transporter in the CNS. Here, we show by quantitative light microscopy that the protein abundance of NHE6 is developmentally regulated in area CA1 of the mouse hippocampus. Within pyramidal neurons, NHE6 was found to localize to discrete puncta throughout the soma and neurites, with noticeable accumulation at dendritic spines and presynaptic terminals. Dual immunolabeling of dendritic spines revealed that NHE6 partially colocalizes with typical markers of early and recycling endosomes as well as with the AMPAR subunit GluA1. Significantly, NHE6-containing vesicles exhibited enhanced translocation to dendritic spine heads during NMDA receptor (NMDAR)-dependent long-term potentiation. These data suggest that NHE6 may play a unique, previously unrecognized, role at glutamatergic synapses that are important for learning and memory.
Starting Page	595
Ending Page	610
Page Count	16
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/33/2/595.full.pdf
PubMed reference number	23303939v1
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.2583-12.2013
DOI	10.1523/jneurosci.2583-12.2013
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume Number	33
Issue Number	2
Language	English
Access Restriction	Open
Subject Keyword	AMPA Receptors Autistic Disorder CA1 field Cell body of neuron Dendritic Spines Endosomes GRIA1 gene Immunoglobulin lambda-Chains Long-Term Potentiation Mental Retardation N-Methyl-D-Aspartate Receptors N-Methylaspartate Neurites Neurodevelopmental Disorders Postsynaptic Membrane Presynaptic Terminals Pyramidal Cells SLC9A6 gene Synapses Vertebral column Vesicle (morphologic abnormality) X-Linked Combined Immunodeficiency Diseases chemosensitization/potentiation
Content Type	Text
Resource Type	Article

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