NDLI: Intravenous Injection of Autologous Mesenchymal Stem Cells for Treatment of Spinal Cord Injury: —医師主導治験による実用化—

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Intravenous Injection of Autologous Mesenchymal Stem Cells for Treatment of Spinal Cord Injury: —医師主導治験による実用化—

Content Provider	Semantic Scholar
Author	Honmou, Osamu
Copyright Year	2016
Abstract	1 .脊髄再生の最近の動向難治性神経疾患である脊髄損傷に対するブレークスルーとして再生医療が期待されており,各種の幹細胞を用いた臨床試験がすでにはじまっている.しかし,これまでのところ良好な結果は報告されていない. 2010年,米国の Geron社によって,ヒト embyonic stem cell(ES細胞)由来の細胞製剤を脊髄損傷患者に対して移植する臨床試験が開始された.しかし,4例に投与した後,2011年,臨床試験を中断し,同社の幹細胞事業を売却することとなった. また,米国の Stem cell社は,ヒト胎児脳由来の神経幹細胞を脊髄損傷患者に対して移植する臨床試験を 2013 年より実施していたが,2016年 5月,試験を中断し,事業売却に踏み切った. 両者に共通していることは,再生能力が高いと考えられている幹細胞もしくは前駆細胞を他家移植として,損傷部の局所に注入していることである.われわれは,これらの事例から学び,失敗の原因を考察し,今後の研究に生かしていく必要がある.
Starting Page	248
Ending Page	250
Page Count	3
File Format	PDF HTM / HTML
DOI	10.2531/spinalsurg.30.248
Volume Number	30
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/spinalsurg/30/3/30_248/_pdf
Alternate Webpage(s)	https://doi.org/10.2531/spinalsurg.30.248
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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