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近交系ハムスターにおけるB. pahangiの研究3. CBNハムスターの感受性とdiethylcarbamazineを用いた治療実験
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kimura, Eisaku Shigeno, Shizugi Shimada, Masaaki Aoki, Yoshiki |
| Copyright Year | 2019 |
| Abstract | The susceptibility of inbred male CBN hamsters to Brugia pahangi infection was studied. The animals infected subcutaneously with 100 infective larvae showed 100% microfilaremia with the average prepatent period of 74.5 days. The average microfilarial density (geometric mean) at 20 weeks postinfection was 53.5/40 cmm of blood. The rate of adult worm recovery ranged from 5 to 54% with the average of 25.4%. They were recovered from the testis, peritesticular tissues, and the heart and lungs. The effect of diethylcarbamazine citrate (DEC) against microfilariae, 3rd and 4th stages of larvae, and adult worms was studied. For the treatment of developing stages of larvae, intratesticularly-infected CBN hamsters were used. DEC was confirmed to be effective against microfilariae and 3rdand 4th-stage larvae, but the effect was less marked against adult worms. The advantages of intratesticular route of infection for chemotherapeutic studies were discussed. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/4408/1/tm27_02_06_t.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
