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Dendritic Cell Ablation Impairs Lymphopenia-Driven Proliferation of Naive and Memory CD 8 T Cells 1
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zaft, Tami Sapoznikov, Anita Krauthgamer, Rita Littman, Dan R. Jung, Steffen |
| Copyright Year | 2005 |
| Abstract | The peripheral lymphocyte pool size is governed by homeostatic mechanisms. Thus, grafted T cells expand and replenish T cell compartments in lymphopenic hosts. Lymphopenia-driven proliferation of naive CD8 T cells depends on self-peptide/MHC class I complexes and the cytokine IL-7. Lymphopenia-driven proliferation and maintenance of memory CD8 T cells are MHC independent, but are believed to require IL-7 and contact with a bone marrow-derived cell that presents the cytokine IL-15 by virtue of its high affinity receptor (IL-15R ). In this study we show that optimal spontaneous proliferation of grafted naive and memory CD8 T cells in mice rendered lymphopenic through gene ablation or irradiation requires the presence of CD11c dendritic cells. Our results suggest a dual role of CD11c dendritic cells as unique APC and cytokine-presenting cells. The Journal of Immunology, 2005, 175: 6428–6435. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://med.nyu.edu/skirball-lab/littmanlab//publications/zaft_cd11c%20DCs.pdf |
| Alternate Webpage(s) | http://saturn.med.nyu.edu/research/mp/littmanlab/publications/zaft_cd11c%20DCs.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
