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A Major Role for Memory CD4 T Cells in the Control of Lymphopenia-Induced Proliferation of Naive CD4 T Cells
| Content Provider | Scilit |
|---|---|
| Author | Bourgeois, Christine Kassiotis, George Stockinger, Brigitta |
| Copyright Year | 2005 |
| Description | In a state of lymphopenia, naive and memory CD4 T cells compete with each other for expansion at the expense of naive T cells. This competition prevents the proliferation as well as the phenotypic and functional conversion of naive T cells to “memory-like” T cells and may consequently prevent immune pathology frequently associated with lymphopenia-induced proliferation of naive cells. However, in T cell replete mice, memory T cells do not compete with naive T cells, indicating independent homeostatic control of naive and memory CD4 T cells in conditions that do not involve profound lymphopenia. Moreover, within the memory compartment, subsequent generation of new memory T cells precludes the survival of memory-like T cells. Thus, memory T cells have a major role in the control of lymphopenia-induced proliferation of naive cells because they inhibit both the generation of memory-like T cells and their persistence within the memory compartment. |
| Ending Page | 5323 |
| Page Count | 8 |
| Starting Page | 5316 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.174.9.5316 |
| Journal | The Journal of Immunology |
| Issue Number | 9 |
| Volume Number | 174 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2005-05-01 |
| Access Restriction | Open |
| Subject Keyword | Naive T Cells Proliferation of Naive Lymphopenia Induced Proliferation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
