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CD25+CD4+ regulatory T cells and memory T cells prevent lymphopenia-induced proliferation of naive T cells in transient states of lymphopenia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bourgeois, Christine Stockinger, Brigitta |
| Copyright Year | 2006 |
| Abstract | Lymphopenia has been associated with autoimmune pathology and it has been suggested that lymphopenia-induced proliferation of naive T cells may be responsible for the development of immune pathology. In this study we demonstrate that lymphopenia-induced proliferation is restricted to conditions of extreme lymphopenia, because neither naive nor memory T cells transferred into T cell-depleted hosts proliferate unless the depletion exceeds 90% of the peripheral repertoire. Memory CD4 T cells as well as regulatory CD4 T cells proved to be relatively resistant to depletion regimes, and both subsets restrict the expansion and phenotypic conversion of naive T cells by an IL-7R-dependent mechanism. It therefore seems unlikely that lymphopenia-induced proliferation of peripheral T cells causes deleterious side effects that result in immune pathology in states of partial and transient lymphopenia. |
| File Format | PDF HTM / HTML |
| DOI | 10.4049/jimmunol.177.7.4558 |
| PubMed reference number | 16982893 |
| Journal | Medline |
| Volume Number | 177 |
| Issue Number | 7 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/jimmunol/177/7/4558.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.4049/jimmunol.177.7.4558 |
| Journal | Journal of immunology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |