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Acetylation Enhances the Promoting Role of AIB1 in Breast Cancer Cell Proliferation
| Content Provider | Semantic Scholar |
|---|---|
| Author | You, Dingyun Zhao, Hongbo Wang, Yan Jiao, Yang Lu, Minnan Yan, Shan Tao |
| Copyright Year | 2016 |
| Abstract | The oncogene nuclear receptor coactivator amplified in breast cancer 1 (AIB1) is a transcriptional coactivator, which is overexpressed in various types of human cancers, including breast cancer. However, the molecular mechanisms regulating AIB1 function remain largely unknown. In this study, we present evidence demonstrating that AIB1 is acetylated by MOF in human breast cancer cells. Moreover, we also found that the acetylation of AIB1 enhances its function in promoting breast cancer cell proliferation. We further showed that the acetylation of AIB1 is required for its recruitment to E2F1 target genes by E2F1. More importantly, we found that the acetylation levels of AIB1 are greatly elevated in human breast cancer cells compared with that in non-cancerous cells. Collectively, our results shed light on the molecular mechanisms that regulate AIB1 function in breast cancer. |
| Starting Page | 663 |
| Ending Page | 668 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 27665502 |
| Alternate Webpage(s) | https://doi.org/10.14348/molcells.2016.2267 |
| DOI | 10.14348/molcells.2016.2267 |
| Journal | Molecules and cells |
| Volume Number | 39 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | BRCA1 gene Breast Cancer Cell Cell Proliferation E2F1 wt Allele HEATR6 gene Mammary Neoplasms Oncogenes Promotion (action) Protein Acetylation Receptors, Nuclear Transcription Coactivator Transcription, Genetic steroid receptor coactivator AIB1 |
| Content Type | Text |
| Resource Type | Article |
