NDLI: SRC-3 : a transcriptional coactivator and therapeutic target in cancer

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SRC-3 : a transcriptional coactivator and therapeutic target in cancer

Content Provider	Semantic Scholar
Author	Yan, Fei Wu, Shaofang
Copyright Year	2012
Abstract	Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), a transcription coactivator, is frequently overexpressed in multiple type of human cancers, including breast, ovarian, prostate, pancreatic, lung, and colorectal cancers. SRC-3 not only interacts with multiple nuclear hormone receptors but also broad-spectrum of non-nuclear-receptor transcription factors to enhance their transcriptional activities. Furthermore, dynamic posttranslational modifications of SRC-3 efficiently modulate this protein in different signaling pathways, and regulate its coactivator activity during transcription. In addition, SRC-3 modulates primary tumor initiation and expansion, and also plays important roles during tumor cell motility and invasion, and metastasis. As previous studies has validated SRC-3 as an oncogene, and indicated that SRC-3-dependent cancers are frequently resistant to traditional chemotherapeutics, the development of small molecule inhibitors that target SRC-3 becomes a feasible way to develop novel anti-cancer agents.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.postdocjournal.com/file_journal/546_12632124.pdf
Language	English
Access Restriction	Open
Subject Keyword	Antineoplastic Agents BRCA1 gene Colorectal Neoplasms Hormone Receptor Leukemia, B-Cell Mammary Neoplasms NCOA3 gene Neoplastic Cell Nuclear Hormone Receptors Oncogenes Post-Translational Protein Processing Prostatic Neoplasms Receptors, Steroid Small Molecule Steroids Structure of parenchyma of lung TRANSCRIPTION FACTOR Therapeutic Targets Database Transcription (software) Transcription Coactivator Transcription Initiation Transcription, Genetic Tumor Initiation primary tumor steroid receptor coactivator AIB1
Content Type	Text
Resource Type	Article

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