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BOAA selectively enhances l-glutamate release from guinea pig hippocampal mossy fiber synaptosomes
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gannon, Robert L. Terrian, David M. |
| Copyright Year | 1989 |
| Abstract | The neurotoxic amino acids beta-N-oxalylamino-L-alanine (BOAA) and beta-N-methylamino-L-alanine (BMAA) were evaluated for possible effects on spontaneous and stimulus-evoked release of L-glutamate (L-Glu) and dynorphin A(1-8)-like immunoreactivity (LI) from guinea pig hippocampal mossy fiber synaptosomes. BOAA (200 microM), but not BMAA (1 mM), was found to significantly increase both basal cytosolic and KCl-stimulated vesicular release of L-Glu. Neither BOAA nor BMAA had any effect on dynorphin A(1-8)-LI release from these synaptosomes. This is the first report describing a presynaptic facilitatory action of BOAA upon L-Glu release; an effect which may contribute to the neurotoxic properties of this proposed environmental toxin. |
| Starting Page | 289 |
| Ending Page | 294 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(89)90833-1 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304394089908331 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304394089908331?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 2575728 |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2889%2990833-1 |
| Journal | Medline |
| Volume Number | 107 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
