Domoic acid enhances the K+-evoked release of endogenous glutamate from guinea pig hippocampal mossy fiber synaptosomes

Content Provider	Semantic Scholar
Author	Terrian, David M. Conner-Kerr, Teresa A. Privette, Thomas H. Gannon, Robert L.
Copyright Year	1991
Abstract	The presynaptic effects of domoic acid (Dom) on hippocampal mossy fiber synaptic transmission were examined using a subcellular fraction enriched in mossy fiber synaptosomes. Domoic acid significantly increased the K(+)-evoked release of endogenous glutamate from superfused guinea pig mossy fiber synaptosomes. The presynaptic facilitation produced by Dom was dose-dependent and was antagonized by the prior application of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). At a concentration of 30 microM, both domoic acid and kainic acid significantly increased the extent to which membrane depolarization augmented the availability of cytosolic free calcium in mossy fiber synaptosomes. These results are consistent with the suggestion that domoic acid enhances the release of mossy fiber neurotransmitters in the guinea pig hippocampus through the activation of a CNQX-sensitive presynaptic receptor.
Starting Page	303
Ending Page	307
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/0006-8993(91)90945-R
PubMed reference number	1680526
Journal	Medline
Volume Number	551
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/000689939190945R
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/000689939190945R?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0006-8993%2891%2990945-R
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article