Loading...
Please wait, while we are loading the content...
Similar Documents
Ibotenate stimulates glutamate release from guinea pig cerebrocortical synaptosomes: inhibition by l-2-amino-4-phosphonobutyrate (l-AP4)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jones, J. G. Roberts, Peter J. |
| Copyright Year | 1990 |
| Abstract | Ibotenate induced a concentration- and largely calcium-dependent release of endogenous glutamate from guinea pig cerebro-cortical synaptosomes. In the absence of Mg2+, the response to ibotenate was enhanced through a mechanism involving N-methyl-D-aspartate (NMDA) receptors; this component was sensitive to the NMDA antagonist 2-amino-7-phosphonoheptanoate (AP7). In the presence of Mg2+, the ibotenate-induced Ca2(+)-dependent release was abolished by L-2-amino-4-phosphonobutyrate (L-AP4). It is suggested that presynaptic 'L-AP4 receptors' exist in guinea pig cerebral cortex, at which ibotenate acts to facilitate glutamate release. L-AP4 may act as an antagonist, or partial agonist of weak intrinsic activity. |
| Starting Page | 228 |
| Ending Page | 232 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(90)90373-H |
| PubMed reference number | 1970860 |
| Journal | Medline |
| Volume Number | 111 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/030439409090373H |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/030439409090373H?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2890%2990373-H |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
