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Intraepithelial NK cell-derived IL-13 induces intestinal pathology associated with nematode infection.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Grencis, Richard K. |
| Copyright Year | 2005 |
| Abstract | IL-13 is a Th2-derived cytokine associated with pathological changes in asthma and ulcerative colitis. Moreover, it plays a major role in the control of gut nematode infection and associated immunopathology. The current paradigm is that these effects are due to T cell-derived IL-13. We show in this study that an innate source of IL-13, the intraepithelial NK cell, is responsible for the disruption of intestinal tissue architecture and induction of goblet cell hyperplasia that characterizes infection with the intestinal helminth Trichinella spiralis. IL-13 or IL-4Ralpha (but not IL-4) null mice failed to induce intestinal pathology. Unexpectedly, SCID and athymic mice developed the same pathology found in immunocompetent mice following infection. Moreover, immunodeficient mice expressed IL-13 in the intestine, and abnormal mucosal pathology was reduced by in vivo administration of a soluble IL-13 antagonist. IL-13 expression was induced in non-T intraepithelial CD3- NK cells. Epithelial cells expressed the IL-13 signaling receptor, IL-13Ralpha1, and after infection, IL-4Ralpha. Furthermore, the soluble IL-13 decoy receptor IL-13Ralpha2, which regulates IL-13 responses, was also induced upon infection. These data provide the first evidence that intestinal tissue restructuring during helminth infection is an innate event dependent on IL-13 production by NK cells resident in the epithelium of the intestine. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jimmunol.org/content/jimmunol/175/5/3207.full.pdf |
| PubMed reference number | 16116211v1 |
| Volume Number | 175 |
| Issue Number | 5 |
| Journal | Journal of immunology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cellular Phone Chronic Lymphocytic Leukemia Goblet Cells Helminths Immunocompetent Immunologic Deficiency Syndromes Interleukin-13 Receptor alpha1 Subunit Intestinal Wall Tissue Mucous Membrane Natural Killer Cells Nematode infections SCID Mice Ulcer Ulcerative Colitis cytokine immunopathology specialty |
| Content Type | Text |
| Resource Type | Article |
