Loading...
Please wait, while we are loading the content...
Similar Documents
IL-33, a potent inducer of adaptive immunity to intestinal nematodes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Humphreys, Neil E. Hepworth, Matthew R. Liew, Foo Yew Eddy Grencis, Richard K. |
| Copyright Year | 2008 |
| Abstract | IL-33 (IL-1F11) binds ST2 (IL-1R4), both of which are associated with optimal CD4(+) Th2 polarization. Exogenous IL-33 drives induction of Th2-associated cytokines and associated pathological changes within the gut mucosa. Th2 polarization is also a prerequisite to expulsion of the intestinal-dwelling nematode Trichuris muris. In this study, we demonstrate that IL-33 mRNA is expressed early during parasite infection and susceptible mice can be induced to expel the parasite by a regime of exogenous IL-33 administration. IL-33 prevents an inappropriate parasite-specific Th1-polarized response and induces IL-4, IL-9, and IL-13. This redirection requires the presence of T cells and must occur at the initiation of the response to the pathogen. Interestingly, exogenous IL-33 also induced thymic stromal lymphopoietin mRNA within the infected caecum, an epithelial cell-restricted cytokine essential for the generation of Th2-driven parasite immunity. IL-33 also acts independently of T cells, altering intestinal pathology in chronically infected SCID mice, leading to an increased crypt length and intestinal epithelial cell proliferation, but reducing goblet cell hyperplasia. Thus, the ability of IL-33 to induce Th2 responses has functional relevance in the context of intestinal helminth infection, particularly during the initiation of the response. |
| Starting Page | 3175 |
| Ending Page | 3175 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jimmunol.org/content/jimmunol/180/4/2443.full.pdf |
| PubMed reference number | 18250453v1 |
| Volume Number | 180 |
| Issue Number | 4 |
| Journal | Journal of immunology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cecum Epithelial Cell Proliferation Goblet Cells Helminths IL33 protein, human Immunity Immunity, Innate Inducer Interleukin-33 Intestinal Diseases, Parasitic Intrinsic drive Leukemia, B-Cell Mucous Membrane Nematodes Pathogenic organism SCID Mice Streptobacillus moniliformis Transcription Initiation cytokine |
| Content Type | Text |
| Resource Type | Article |
