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Visualization of chandelier cell axons by parvalbumin immunoreactivity in monkey cerebral cortex.
| Content Provider | Semantic Scholar |
|---|---|
| Author | DeFelipe, Javier Hendry, Stewart H. C. Jones, Edward G. |
| Copyright Year | 1989 |
| Abstract | Antibodies directed against the calcium-binding protein parvalbumin label a subpopulation of gamma-aminobutyric acid-releasing neurons in the cerebral cortex that is thought to have particular metabolic and physiological properties. The chandelier cell is a well-characterized morphological type of gamma-aminobutyric acid-releasing cortical interneuron, the axon of which possesses very distinctive terminal portions located around the initial axon segments of pyramidal cells. In the pre- and postcentral gyri of the monkey, we found that these distinctive terminal portions of chandelier cell axons were immunocytochemically stained for parvalbumin in a manner that reveals their complete structure. The chandelier cell axons were identified light-microscopically as short, vertically oriented rows of parvalbumin-positive puncta (PV-Rs). The PV-Rs varied in both length and complexity and were located beneath unstained pyramidal cells. PV-Rs were very numerous in layers II-III, where most pyramidal cells appeared to have a PV-R beneath them. Fewer PV-Rs were found in deeper layers, and in layer VI PV-Rs were rare. With EM all PV-Rs could be seen to form multiple synaptic contacts of the symmetrical type on the initial segments of pyramidal cell axons. Parvalbumin immunoreactivity can therefore be used as a reliable marker for chandelier cell axons. |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pnas.org/content/86/6/2093.full.pdf |
| PubMed reference number | 2648389v1 |
| Volume Number | 86 |
| Issue Number | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Axon Basal Ganglia Diseases Calcium Cerebral cortex Electron Microscopy Interneurons Metabolic Process, Cellular PVALB gene Parvalbumins Penicillin V Pyramidal Cells RS 43285-193 anatomical layer gamma-Aminobutyric Acid |
| Content Type | Text |
| Resource Type | Article |
