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Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity.
| Content Provider | Semantic Scholar |
|---|---|
| Author | He, Ling-jie Liu, Nan Cheng, Tianlin Chen, Xiao-jing Li, Yi-ding Shu, You-sheng Qiu, Zilong Zhang, Xiao-Hui |
| Copyright Year | 2014 |
| Abstract | Mutations in the X-linked gene encoding the transcriptional modulator methyl-CpG-binding protein 2 (MeCP2) impair postnatal development of the brain. Here we use neuronal-type specific gene deletion in mice to show that conditional Mecp2 deletion in GABAergic parvalbumin-expressing (PV) cells (PV-Mecp2(-/y)) does not cause most Rett-syndrome-like behaviours, but completely abolishes experience-dependent critical period plasticity of primary visual cortex (V1) that develops normal visual functions. However, selective loss of Mecp2 in GABAergic somatostatin-expressing cells or glutamatergic pyramidal cells does not affect the critical period plasticity. MeCP2-deficient PV cells exhibit high intrinsic excitability, selectively reduced efficacy of recurrent excitatory synapses in V1 layer 4 circuits, and decreased evoked visual responses in vivo. Enhancing cortical gamma-aminobutyric acid (GABA) inhibition with diazepam infusion can restore critical period plasticity in both young and adult PV-Mecp2(-/y) mice. Thus, MeCP2 expression in inhibitory PV cells during the critical period is essential for local circuit functions underlying experience-dependent cortical plasticity. |
| Starting Page | 5036 |
| Ending Page | 5036 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://brain.bnu.edu.cn/home/xhzhang/pdf/MeCP2-regulates-CP-NatCommun2014.pdf |
| PubMed reference number | 25297674v1 |
| Alternate Webpage(s) | https://doi.org/10.1038/ncomms6036 |
| DOI | 10.1038/ncomms6036 |
| Journal | Nature communications |
| Volume Number | 5 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cerebral cortex Deletion Mutation Diazepam Gene Deletion Modulator Device Component PVALB gene Penicillin V Pyramidal Cells Synapses Transcription, Genetic gamma-Aminobutyric Acid |
| Content Type | Text |
| Resource Type | Article |
