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Intravascular ultrasound evaluation after sirolimus eluting stent implantation for de novo and in-stent restenosis lesions.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Degertekin, Muzaffer Lemos, Pedro Alves Lee, Chi-Hang Tanabe, Kengo Sousa, J. Eduardo Morais Rego Abizaid, Alexandre S. Regar, Evelyn Sianos, George Giessen, Willem J. Van Der Feyter, Pim J. De Wuelfert, Egon Popma, Jeffrey J. Serruys, Patrick W. |
| Copyright Year | 2004 |
| Abstract | AIMS The aim of this study is to compare the efficacy of sirolimus-eluting stents (SES) on neointimal growth and vessel remodelling for in-stent restenosis versus de novo coronary artery lesions using serial intravascular ultrasound (IVUS). METHODS AND RESULTS The study population consisted of 86 patients with in-stent restenosis (ISR) (n=41) or de novo lesions (n=45) treated with SES and evaluated by IVUS post-procedure and at follow-up. One 18-mm SES was used for de novo lesions while 16 patients with ISR received >1SES (total stented length 17.9 mm vs 22.0 mm respectively; P=0.004). At follow-up, no differences were observed between the ISR and de novo groups with respect to changes in the mean external elastic membrane (1.7% vs 1.3%; P=0.53), plaque behind the stent (1.2% vs 3.4%; P=0.49), and lumen areas (0.7% vs 1.9%; P=0.58). No positive remodelling or edge effect was observed. A gap between stents was observed in two patients with ISR, where more prominent, though non-obstructive, neointimal proliferation was noted. CONCLUSION Sirolimus-eluting stenting is equally effective at inhibiting neointimal proliferation in de novo and ISR lesions without inducing edge restenosis or positive vascular remodelling. |
| Starting Page | 204328 |
| Ending Page | 204328 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/eurheartj/25/1/10.1016_j.ehj.2003.10.012/1/32.pdf?Expires=1491667027&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=C~4YSUSptpIIiDcDEF0oZ4u~0XfaDKDQpX9~1NdaEvs~ueNthGDDOI~beaWnsh60VZVXqmHGYGmqAmAhAbUGx3B5Efru-Y3uN8fEZX~zL8MyxAt0r98t7yoL6jV0ldhsXeACAjnRwNgZK9SpHZSIsHJbTfjrrWdYXTrWql-~bsN5~fuA0NuoMdMK3bc9KauXBb9RHCbAVphKxxx0GCpJg8JR7wYJaZjwfz~TnEYkvZDqFVxXoPstCAtlLaRQineNqg6bW1rHsz6mPV8U5nA9IoaEFyUIsgtKinzQVG-jxyCAZiiOndJP8OyGt3wUzVy~E8x9au2wXDOXktfJGbXz6Q__ |
| PubMed reference number | 14683740v1 |
| Volume Number | 25 |
| Issue Number | 1 |
| Journal | European heart journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Angiolymphoid hyperplasia Blood Vessel Tissue Cerebrovascular Disorders Dental Plaque Disseminated Intravascular Coagulation External Elastic Membrane Intravascular ultrasound Manuscripts Patients Sirolimus Stent Device Component Stent, device Units Of Measure - lumen Vascular Diseases restenosis |
| Content Type | Text |
| Resource Type | Article |
